Adenosine turnover in GtoPdb v.2023.1

A multifunctional, ubiquitous molecule, adenosine acts at cell-surface G protein-coupled receptors, as well numerous enzymes, including protein kinases and adenylyl cyclase. Extracellular is thought to be produced either by export or metabolism, predominantly through ecto-5’-nucleotidase activity (also producing inorganic phosphate). It inactivated extracellular metabolism via deaminase ammonia) or, following uptake nucleoside transporters, kinase (requiring ATP co-substrate). Intracellular may cytosolic 5’-nucleotidases S-adenosylhomocysteine hydrolase L-homocysteine).